|
|
 
 |
Professor Carol Kellogg
Office: Meliora 186, x5-4801
Office Hours: After class or by appointment
e-mail: kellogg@bcs.rochester.edu
Web: http://www.bcs.rochester.edu/neuro/
Workshop Leader: Andrew Hart
e-mail: ah007k@mail.rochester.edu
Course Intent:
This course is intended to introduce you to the field of neurochemistry. Basic neurochemistry includes study of the chemical composition of the brain, brain metabolism and the chemistry of neurotransmission. Methodological development over the latter part of the 20th century has allowed investigation down to nuclear levels. About half of the course will cover the chemistry of neural transmission and a quarter will cover chemical composition and metabolism. The discipline of behavioral neurochemistry includes topics that range from study of the neurochemical mechanisms that underlie normal behavior to behavioral sequellae that result from severe neurochemical abnormalities. These issues will be considered in the final quarter of the course in a unit designated as functional neurochemistry. However, throughout the course, the functional aspects of all neurochemical mechanisms will be discussed. An introductory knowledge of biochemistry will be helpful in understanding the material presented. NSC 201 is a prerequisite for this course.
Texts:
No single text satisfactorily covers all the material included in this course. Chapters will be assigned from the following books, all of which are on 2-hr. reserve at Carlson Library.
Basic Neurochemistry, Molecular, Cellular and Medical Aspects. Sixth Edition. Siegel, G.J., Agranoff, B.W., Albers, R.W., Fisher, S.K., Uhler, M.D. (eds.), Lippincott Williams & Wilkins, 1999. Twenty-five of the 54 chapters in this book have been assigned so these chapters cannot be placed on electronic reserve. This book should be purchased.
Neurobiology of Mental Illness, Charney, D.S., Nestler, E.J., Bunney, B.S. (eds.), Oxford University Press, 1999. Eight chapters in this book have been assigned. These chapters will be on electronic reserve. There is a more recent edition of this book, but because some students may have the older edition, that edition will be used this year.
The Biochemical Basis of Neuropharmacology, Eighth Edition, Cooper, J.R., Bloom, F.E., Roth, R.H., Oxford University Press, 2003. Three chapters in this book have been assigned as primary reading and four others suggested. The assigned chapters will be on electronic reserve. This edition is not currently available at Carlson library.
Additional assigned readings will be placed on electronic reserve
Examinations:
The course is arranged into four units. An in-class exam will be given at the end of each of the first three units. A take-home exam will cover the fourth unit. Problem analysis workshops will be held for each unit. The take-home exam questions will be handed out at the last class period and the exam will be due on the day that the final exam for the course is scheduled. Each exam will account for 25% of your final grade. The in-class exams involve data analysis and interpretation. The take-home exam will be an essay format and the answers will require integration of diverse material.
| September | 2: |
Overview of the Course. An historical introduction to neurochemistry |
|
| PART ONE: General and Macromolecular Neurochemistry | |||
| September | 7: |
Regulating the Brain Microenvironment Siegel, et al., Sixth Edition, Ch. 32 |
|
| 9: |
Carbohydrate Utilization and Energy Metabolism Siegel, et al., Sixth Edition, Ch. 31 *Paulson, O.B. (2002). Blood-brain barrier, brain metabolism and cerebral blood flow. Eur. Neuropharmacol., 12:494-501. |
||
| 14: |
Proteins in the Brain *Tobin, A.J. (1994) Gene expression in the mammalian nervous system. In. Seigel, et al., Basic Neurochemistry, Fifth Edition, Ch. 24, pp. 493-513; *Charney, et al., Ch. 6 Siegel, et al., Sixth Edition, Ch. 26 | ||
| 16: |
Lipids: Multiple Roles Siegel, et. al, Sixth Edition, Ch. 2,3 *Haag, M. (2003). Essential fatty acids and the brain, Can. J. Psychiatry, 48:195-203. |
||
| 21: |
Calcium: Sculptor and Destroyer of Cells Siegel, et al., Sixth Edition, Ch. 23 |
||
| 23: |
Macromolecular influences in Neuronal Death and Survival Siegel, et. al, Sixth Edition, Ch. 19 and 34, pp.722-728 (Free radicals) | *Haeberlein, S.L.B. (2004) Mitochondrial function in apoptotic neuronal cell death. Neurochem. Research, 29: 521-530. | |
| 28: | EXAM ONE | ||
| PART TWO: Transmitter Neurochemistry: Presynaptic Mechanisms | |||
| 30: |
Acetylcholine *Cooper, et. a l., Ch. 7 Siegel et. al., Sixth Edition, Ch. 10 |
||
| October | 5: |
Catecholamines Siegel, et al., Sixth Edition, Ch. 12 Also, extensive coverage can be found in Cooper, et. al., Chs. 8,9 |
|
| 7: |
Serotonin Siegel, et al., Sixth Edition, Ch. 13 (or Cooper, et al., Ch. 10) |
||
| 12: |
Amino Acids *Cooper, et al., Ch. 6 Siegel, et al., Sixth Edition, Chs. 15,16 |
||
| 14: |
Peptides and Transmitter coexistence Siegel, et al., Sixth Edition, Ch. 18; Cooper, et al., Ch. 11 *Furness, J.B., Morris, J.L., Gibbins, I.L., Costa, M. (1989) Chemical Coding of Neurons and Plurichemical Transmission. Ann. Rev. Pharmacol. Toxicol., 29:298-306. |
||
| 19: |
Other Messengers *Snyder, S.H., Ferris, C.D. (2000) Novel neurotransmitters and their neuropsychiatric relevance. Am. J. Psychiatry, 157:1738-1751 See Also: Siegel, et al., Sixth Ed., Ch.10, pp. 210-211; Ch.17; Ch. 49 |
||
| 21: | EXAM TWO | ||
| PART THREE: Synaptic Neurochemistry: Postsynaptic Mechanisms | |||
| 26: |
Receptors: Overview and Recognition Site Identification Renee Miller, Lecturer *McGonigle, P., Molinoff, P.B., Receptors and signal transduction: Classification and quantification. In: Siegel et al., Fifth Ed., Ch.10, pp. 209-230. *Cooper, et al., Ch. 4 |
||
| 28: |
Receptor-Effector Mechanisms: Ligand-gated Ion Channels Review receptor coverage in Siegel, et al., Sixth Ed., Chs. 11, 15, 16 |
||
| November | 2: |
Receptor-Effector Mechanisms: Second Messenger Systems Siegel et al.,Sixth Edition Chs. 20, 21, 22 Review receptor coverage in chapters on various neurotransmitters |
|
| 4: | Importance of Phosphorylation to Brain Function | Siegel et al, Sixth Edition, Chs. 24, 25 | |
| 9: |
Roles for Neurotransmitters and Their Receptors BS (before synapses) *Weiss, E.R., Maness, P., Lauder, J.M. (1998) Why do neurotransmitters act like growth factors? Perspectives on Develop. Neurobiol., 5: 323-336. *Dreyfus, C.F. (1998) Neurotransmitters and neurotrophins collaborate to influence brain development. Perspectives on Develop. Neurobiol., 5: 389-400. *Barker, J.L. et al. (1998) GABAergic cells and signals in CNS development. Perspectives on Develop. Neurobiol., 5 305-322. |
||
| 11: | EXAM THREE | ||
| PART FOUR: Functional Neurochemistry | |||
| 16: |
Neurochemical Aspects of Neuroplasticity Charney et al., Ch. 5 Siegel, et al., Sixth Ed., Ch 50 *Felician, O., Sandson, T.A. (1999) The neurobiology and pharmacotherapy of AlzheimerÍs Disease. J. Neuropsychiatry and Clinical Neuroscience, 11: 19-31. *Lee, J.L.C., Everitt, B.J., Thomas, K.L. (2004) Independent cellular processes for hippocampal memory consolidation and reconsolidation. Science, 304: 839-843. |
||
| 18: |
Neural Mechanisms of Adaptive Responses: Coping with challenge Review, Bear, et al., Neuroscience, Ch. 15, pp. 496-512 (text for NSC 201) *Vermetten, E., Bremner, D. (2002). Circuits and systems in stress. Depression and Anxiety, 15:126-147. *Charney, D.S. (2004) Psychobiological mechanisms of resilience and vulnerability: Implications for successful adaptation to extreme stress. Am. J. Psychiatry, 161: 195-216. |
||
| 23: |
Neurochemical Aspects of Major Psychiatric Disorders I: Schizophrenia, a disorder of altered connectivity? *Charney, et al., Chs. 18, 19 *Sawa, A., Pletnikov, M.V., Kamiya, A. (2004) Neuron-glia interactions clarify genetic-environmental links in mental illness. Trends in Neuroscience, 27: 294-297 Siegel, et al., Sixth Ed., Ch. 51 |
||
| 25: | Thanksgiving Recess | ||
| 30: |
Neurochemical Aspects of Major Psychiatric Disorders II: Mood disorders, disorders of second messenger dysfunction? *Charney, et al., Ch. 26 Siegel, et al., Sixth Ed., Ch. 52 |
||
| December | 2: |
Neurochemical Aspects of Substance Abuse Disorders *Charney, et al., Chs. 41 Siegel, et al., Sixth Ed., Ch. 53 *Wise, R.A. (2002) Brain reward circuitry: Insights from unsensed incentives. Neuron, 36: 229-240. |
|
| 7: |
Neurochemistry of motor function and dysfunction *Pollack, A. (2001). Anatomy, physiology and pharmacology of the basal ganglia. Neurologic Clinics, 19:523-534. *Siderowf, A., Stern, M. (2003) Update on Parkinson Disease, Ann. Intern. Med. 138: 651-658. *Tobin, A.J., Singer, E.R. (2000). HuntingtonÍs Disease: The challenge for cell biologists. Trends in Cell Biology, 10:531-536. *Young, A. (2003) Huntingtin in health and disease. J. Clin. Invest., 111: 299-302. |
||
| 9: | Video: MPTP-induced Parkinson's Disease; Hand out final exam | ||
| 18: | Final Take-Home Exam Due by 4:00 pm | ||
Tentatively, workshops will be held Tuesdays at 6:30 or 6:45 p.m. in Meliora 109 (NSC lab)
Workshop 1: Tuesday, Sept. 14
Workshop 2: Tuesday, Sept 21
Workshop 3: Tuesday, Oct. 12
Workshop 4: Tuesday, October 19
Workshop 5: Tuesday, November 2
Workshop 6: Tuesday, November 9
Workshop 7: Tuesday, December 7
|
Last modified: 9/1/2004
questions and comments about this site |