NSC 243: Lecture Schedule

Only students who are enrolled in the course may access the readings online. You must be logged into Blackboard to download the course readings.

All chapters and page numbers are from Siegel, et al.

Date	Topic	Readings
09/02	Neurochemistry: An Historical Overview Introduction to Chemically Mediated Synaptic Transmission	Ch 10
Part One—Synaptic Neurochemistry: Presynaptic Mechanisms
09/07	Acetylcholine	Ch 11 *Cooper, Bloom, & Roth 2003
09/09	Catecholamines	Ch 12
09/14	Serotonin	Ch 13
09/16	Glutamic Acid	Ch 15
09/21	GABA & Glycine	Ch 16
09/23	Peptides, Transmitter Co-existence	Ch 18 *Furness et al. 1989
09/28	Other Chemical Messengers: Retrograde Messengers & Extraneuronal Messengers	Ch 17, 27, 52 *Snyder & Ferris 2000
09/30	EXAM ONE
Part Two—Synaptic Neurochemistry: Postsynaptic Cell Signaling Mechanisms
10/05	Receptors: Recognition Site	McGonigle & Molinoff; Cooper, Bloom, & Roth 2003 Ch 4
10/07	Receptor-Effector Mechanisms: Ligand-gated Ion Channels	Ch 11, pp. 197-202 (Nicotinic Receptor) Ch 15, pp. 273-280 (Glutatmate Receptors) Ch 16, pp. 293-298 (GABA Receptors)
10/12	Receptor-Effector Mechanisms: Second Messenger Systems	Chs 19, 20, 21 Ch 12, pp. 217-223 (Catecholamine Receptors) Ch 13, pp. 240-247 (Serotonin Receptors) Ch 11, pp. 203-208 (Muscarinic Receptors) Ch 17, pp. 312-314 (Adenosine Receptors) Ch 18, pp. 326-328 (Peptides)
10/14	Phosphorylation & Brain Function	Chs 23-24
10/19	Importance of Calcium to Brain Function	Ch 22
10/21	Transmitter Roles BS (Before Synapses)	Weiss, Maness, & Lauder 1998; Ben-Ari 2002; *Represa & Ben-Ari 2005
10/26	EXAM TWO
Part Three—Metabolic Chemistry
10/28	Carbohydrates & Energy Metabolism	Ch 31 *Laterra et al. 1999
11/02	Amino Acids & Protein Function in Brain	Ch 26 Ch 40, pp. 668-673 Hymen & Nestler 2004; Borelli et al. 2008; *Zamore & Haley 2005
11/04	Brain Lipids: Multiple Roles	Chs 3, 33 Ch 56, pp. 919-921 (Cannanbinoids)
11/09	Survival & Death of Neurons	Chs 32, 35 Zhao, Deng, & Gage 2008; Kempermann 2008
11/11	EXAM THREE
Part Four—Applied Neurochemistry: Mini Symposia
11/16	Symposium One
11/18	Symposium Two
11/23	Symposium Three
11/25	Thanksgiving: NO CLASS
11/30	Symposium Four
12/02	Symposium Five
12/07	Symposium Six
12/09	Symposium Seven

Symposia Titles

Neurochemical Mechanisms of Plasticity: Learning and Memory
Reading: Ch. 53
Neuropathology Underlying Alzheimer's Disease
Reading: Ch 47
Basal Ganglia Function and Dysfunction
Reading: Ch. 46
Addiction
Reading: Ch. 56
Neurochemistry of Schizophrenia
Reading: Ch 54
Mood and Anxiety Disorders
Reading: Ch. 55
Neurobiology of epilepsies
Reading: Ch. 37

The date of each symposium will be announced on Sept. 16

Workshops

Two workshops will be offered during each unit. Workshops will be held in Meliora 111, the room where the neurobiology lab is taught. Dates and times of the workshops will be available at the start of class.

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