NSC 243: Lecture Schedule

Only students who are enrolled in the course may access the readings online. You must be logged into Blackboard to download the course readings.

All chapters and page numbers are from Siegel, et al.
*Article is in Blackboard

Date	Topic	Readings
08/31	Neurochemistry: An Historical Overview Introduction to Chemically Mediated Synaptic Transmission \| slides \| outline	Ch 10
Part One—Synaptic Neurochemistry: Presynaptic Mechanisms
09/07	Acetylcholine \| slides \| outline	Ch 11 *Cooper, Bloom, & Roth 2003
09/12	Catecholamines \| slides \| outline	Ch 12
09/14	Serotonin \| slides \| outline	Ch 13
09/19	Glutamic Acid \| slides \| outline	Ch 15
09/21	GABA & Glycine \| slides \| outline	Ch 16
09/26	Peptides, Transmitter Co-existence \| slides \| outline	Ch 18 *Furness et al. 1989
09/28	Other Chemical Messengers: Retrograde Messengers & Extraneuronal Messengers \| slides \| outline	Ch 17: pp. 303-306, 312-315 (effects on nervous system) Ch 27: all Ch 52: optional Ch 33: pp. 575-584 *Snyder & Ferris 2000
10/03	EXAM ONE
Part Two—Synaptic Neurochemistry: Postsynaptic Cell Signaling Mechanisms
10/05	Receptors: Recognition Site \| slides \| outline	McGonigle & Molinoff Cooper, Bloom, & Roth 2003
10/10	Fall Break
10/12	Receptor-Effector Mechanisms: Ligand-gated Ion Channels \| slides \| outline	Ch 11, pp. 197-202 (Nicotinic Receptor) Ch 15, pp. 273-280 (Glutatmate Receptors) Ch 16, pp. 293-298 (GABA Receptors)
10/17	Receptor-Effector Mechanisms: Second Messenger Systems \| slides \| outline	Chs 19, 20, 21 Ch 12, pp. 217-223 (Catecholamine Receptors) Ch 13, pp. 240-247 (Serotonin Receptors) Ch 11, pp. 203-208 (Muscarinic Receptors) Ch 17, pp. 312-314 (Adenosine Receptors) Ch 18, pp. 326-328 (Peptides)
10/19	Phosphorylation & Brain Function \| slides \| outline	Chs 23-24
10/24	TBD
10/26	Importance of Calcium to Brain Function \| slides \| outline	Ch 22
10/31	Transmitter Roles BS (Before Synapses) \| slides \| outline	Weiss, Maness, & Lauder 1998; Ben-Ari 2002; *Represa & Ben-Ari 2005
11/02	EXAM TWO
Part Three—Metabolic Chemistry
11/07	Amino Acids & Protein Function in Brain \| slides \| outline	Ch 26 Ch 40, pp. 668-673 (Protein Building Activity)
11/09	Brain Lipids: Multiple Roles \| slides \| outline	Chs 3, 33 Ch 56, pp. 919-921 (Cannanbinoids) Hymen & Nestler 2004; Borelli et al. 2008; *Zamore & Haley 2005
11/14	Survival & Death of Neurons \| slides \| slides2 \| outline	Chs 32, 35 Zhao, Deng, & Gage 2008; Kempermann 2008
Part Four—Applied Neurochemistry: Mini Symposia
11/16	Symposium One
11/21	Symposium Two
11/23	Thanksgiving: NO CLASS
11/28	Symposium Three
11/30	Symposium Four
12/05	Symposium Five
12/07	Symposium Six
12/12	Symposium Seven

Symposia Titles

Neurochemical Mechanisms of Plasticity: Learning and Memory (Reading: Ch. 53)
Neuropathology Underlying Alzheimer's Disease (Reading: Ch 47)
Basal Ganglia Function and Dysfunction (Reading: Ch. 46)
Addiction (Reading: Ch. 56)
Neurochemistry of Schizophrenia (Reading: Ch 54)
Mood and Anxiety Disorders (Reading: Ch. 55)
Neurobiology of epilepsies (Reading: Ch. 37)

Workshops

Two workshops will be offered during each unit. Workshops will be held in Meliora 111, the room where the neurobiology lab is taught. Dates and times of the workshops will be available at the start of class.

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