Monday, Wednesday, 4:50-6:05
Fall 1998
| Professor Carol Kellogg | Professor Peter Como |
| Office: Meliora 186 | Office: Meliora 171 |
| Telephone: 5-4801 | Telephone: 5-8726 |
| Office Hours: 4:00-4:30, M &W or by appointment | Office Hours: 4:15-4:45, M & W
or by appointment |
|
e-mail:kellogg@bcs.rochester.edu |
e-mail: como@etin.mct.rochester.edu |
Course Intent: The objective of this course is to present current understanding of the neurobiology of various disorders generally classified as "mental disorders." The working concept to be presented is that all disorders of the brain are "neurobiological disorders." Basic concepts of neurobiology will be presented coincidentally with clinical presentations and a discussion of the clinical management of the various disorders.
Text: We are using the newly published book, "Neurobiology of Mental Illness", D.S. Charney, E.J. Nestler, B.S.Bunney, Oxford University Press, 1999.
Course Evaluation: Five exams accounting for 100% of the final grade will be given. Both take-home and in-class exams are scheduled. The in-class exams may include discussion questions for which study questions will be handed out prior to the in-class exams. Some of the study uestions will be on the exam while other questions may not be identical to the study questions but will be similar.
Lecture Schedule and Assigned Reading
| Jan. 12 | Introduction |
UNIT 1: Basic Concepts of Brain Function
| Neurochemical Systems | Ch.2 | C. Kellogg | |
| Jan. 17 | Signal Transduction | Ch.3, 4 | C. Kellogg |
| Jan. 19 | Mechabisms of Neural Plasticity | Ch. 5 | C. Kellogg |
| Take-Home Problem Set: Due in Jan. 24 |
UNIT 2: Neurobiology of Psychoses
| Jan. 24 | The major psychoses | Ch. 15 | P. Como |
| Jan. 26 | Pharmacotherapy of psychoses | Ch. 22 | P. Como |
| Jan 31 | Neurobiology of Psychoses | Chs. 1, 18, 19, 20 | C. Kellogg |
UNIT 3: Mood Disorders
|
Feb. 2 |
Classification of Mood Disorders | Ch. 23 | P. Como |
| Feb. 7 | Pharmacotherapy of Mood Disorders | Ch. 31 | P. Como |
| Feb. 9 | Neurobiology of Mood Disorders | Ch. 26,27, 30 | C. Kellogg |
| Take-Home Exam over UNITS 2 and 3: Due in Feb. 14 |
UNIT 4: Anxiety Disorders
| Feb. 14 | Classification of anxiety disorders | Ch. 32 | P. Como |
| Feb. 16 | Obsessive-Compulsive disorders | Ch. 37 | P. Como |
| Feb. 21 | Pharmacotherapy of anxiety disorders | P. Como | |
| Feb. 23 | Neurobiology of anxiety disorders I | Ch. 5,34,35,36,38 | C. Kellogg |
| Feb. 28 | Neurobiology of anxiety disorders II | C. Kellogg | |
| March 1 | In-Class Exam over UNIT 4 | ||
| March 6, 8 | Spring Break |
UNIT 5: Addictive disorders
| March 13 | Neural Mechanisms of addiction | Ch 40, 41, 43, 44 | C. Kellogg |
| March 15 | Profile of an addicted brain | Video | C. Kellogg |
UNIT 6: Neurodegenerative Disorders
| March 20 | Neural Mechanisms of Cell Death | C. Kellogg | |
| March 22 | Parkinsonês Disease | P. Como | |
| March 27 | Huntingtonês Disease | P. Como | |
|
March 29 |
Alzheimerês Disease | Ch. 46, 47, 50, 52, 56 | P. Como |
| April 3 | In-Class Exam overUnits 5 and 6 |
UNIT 7: Childhood Onset Disorders
| April 5 | Tourette's syndrome | Ch. 59 | P. Como |
| April 10 | Attention Deficit Disorders | Ch. 60,61,62 | P. Como |
| April 12 | Guest Lecure: Autism | Ch. 58 | P. Rodier |
UNIT 8: Special Topics
| April 17 | Sex Specific Aspects of brain structure and function | Video and Lecture | C. Kellogg |
| April 19 | Eating Disorders | Ch. 68 | P. Como |
| April 24 | Guest Lecture: Sleep and Mood Disorders | Ch. 70 | |
| April 26 | In-Class Exam over Units 7 and 8 |