University of Rochester

James R. Ison

Research Overview

The aim of our research is to understand how the auditory system is able to follow the rapidly changing acoustic signal that characterizes speech, and to determine how age-related changes in temporal acuity may contribute to the problems that elderly listeners have in perceiving speech in noisy environments. Much of the work is based on comparing the changing temporal and spectral abilities of human listeners as they age with those of aging mice, to support physiological studies in mice that may help to understand the central neural bases of presbycusis in humans. We use a combination of methods including sensory judgments in humans and behavioral psychophysics in wild type and in knockout mice, electrophysiological measures of neural activity, and manipulations of neural activity through neurochemical manipulations. The work is conducted in collaboration with colleagues in the departments of Otolaryngology and Neurobiology and Anatomy.

Selected Publications

Conference Presentations

Research Collaborators

Paul D. Allen, Research Assistant Professor, Neurobiology & Anatomy, University of Rochester
Robert D. Frisina, Professor, Department of Otolaryngology, University of Rochester
William E. O'Neill, Associate Professor, Department of Neurobiology & Anatomy, University of Rochester
Joseph P. Walton, Associate Professor, Department of Otolaryngology, University of Rochester

Research Support

This research is supported by the National Institutes of Health (National Institute for Aging) and The Schmitt Foundation on Integrative Brain Research.